Huntingtin Lowering Strategies
نویسندگان
چکیده
منابع مشابه
Huntingtin-lowering strategies in Huntington's disease: antisense oligonucleotides, small RNAs, and gene editing.
The idea to lower mutant huntingtin is especially appealing in Huntington's disease (HD). It is autosomal dominant, so that expression of the mutant allele causes the disease. Advances in RNA and gene regulation provide foundations for the huntingtin gene (both normal and mutant alleles) and possibly the mutant allele only. There is much preclinical animal work to support the concept of gene an...
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Assuming that aggressive behavior negatively affects all aspects of school performance (i.e. self-efficacy, affects, planning, motivation, and lack of outcome control) it would be logical to conclude that learning strategies to control affects can lead to improvements in school performance. To explore this hypothesis a group of 200 accessible students were given a questionnaire on aggressive be...
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Lowering the operating temperature of solid oxide fuel cells (SOFCs) to the intermediate range (500–700 oC) has become one of the main SOFC research goals. High operating temperatures put numerous requirements on materials selection and on secondary units, limiting the commercial development of SOFCs. The present review first focuses on the main effects of reducing the operating temperature in ...
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BACKGROUND Huntington's disease (HD) is caused by the abnormal expansion of the polyglutamine tract in the human Huntingtin protein (polyQ-hHtt). Although this mutation behaves dominantly, huntingtin loss of function also contributes to HD pathogenesis. Indeed, wild-type Huntingtin plays a protective role with respect to polyQ-hHtt induced defects. METHODOLOGY/PRINCIPAL FINDINGS The question ...
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background and aim: it has been several decades since the technology of frequency lowering (fl) has been proposed. however, primary research has revealed no benefits regarding the use of this technique. currently, new methods for fl and improvement of perception of speech and fricative sounds have led to the application of these methods by numerous companies to produce hearing aids. in this stu...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21062146